Figure 2. front view.
The blueish tyrosine sticking out middle under the red blob
is prominently visible. That is YOUR tyrosine (indicated in the
alignment above).
I built a perfect helix of your wildtype sequence. In the four figures below you get a bit an impression of what that helix could look like. I am sure that it will definitely noy be 100% a helix but the part with the high concentration of Aspartic acids most likely is. Not because asp is so good for helices, but as a helix it provides one big closed negative surface to the world. Something like that is not by accident. That is not how nature works.
Your FYD sequence sits at the opposite side of this negative surface.
The sequence looks like (negative residues and the FY indicated; ===== is the part that has a negative face if built as a helix):
MELLSPPLRDIDLTGPDGSLCSFETADDFYDDPCFDSPDLRFFEDLDPRL
| | | | | ||FY|| | | || |
================
Blue : ARG LYS HIS Red : GLU ASP Purple : ASN GLN Yellow : CYS MET Green1 : GLY ALA VAL LEU ILE PRO Green2 : THR SER Green3 : PHE TYR TRP
Figure 1. top view.
In figure 1 we see (Nterminus is right all the time) the big red blob somewhat left of the middle. These are the negative residues among the ===='es in the alignment above. In the next figures we rotate more or less around the horizontal axis.
Figure 2. front view.
The blueish tyrosine sticking out middle under the red blob
is prominently visible. That is YOUR tyrosine (indicated in the
alignment above).
Figure 3. bottom view. (sorry for the funny bar on the top)
Now the red blob is barely visible, because we look from the rear side.
The blueuish ring sticking outbetween the two yellow ones is the
phenylalanine of your FYD motif. The tyrosine is just above it,
but as this tyr is sticking out straight into your eye, it is a bit hard
to see in this few.
Figure 4. the other side view.
Now the tyrosine is clearly visible again (sticking towards the upper right between
the two yellow ones), whereas the phe sticks straight into your eye, just underneath the tyr.
The negative residues are all sticking out in one direction
with their sidechains about 45 degrees away from the axis of the
helix in the Nterminal direction, as is always with helices.
HEADER DUMMY FOR WHATIF COMPND DUMMY SOURCE G. VRIENDS IMMAGINATION AUTHOR G. VRIEND CRYST1 1000.000 1000.000 1000.000 90.00 90.00 90.00 P 1 SCALE1 .001000 0.000000 0.000000 0.00000 SCALE2 0.000000 0.001000 0.000000 0.00000 SCALE3 0.000000 0.000000 0.001000 0.00000 ATOM 1 N MET 1001 1.202 0.848 0.001 1.00 12.00 ATOM 2 CA MET 1001 0.001 0.001 0.001 1.00 12.00 ATOM 3 C MET 1001 -1.249 0.882 0.001 1.00 12.00 ATOM 4 O MET 1001 -2.184 0.661 -0.783 1.00 12.00 ATOM 5 CB MET 1001 0.023 -0.965 1.182 1.00 12.00 ATOM 6 CG MET 1001 1.225 -1.871 1.132 1.00 12.00 ATOM 7 SD MET 1001 1.132 -2.817 -0.430 1.00 12.00 ATOM 8 CE MET 1001 -0.435 -3.660 -0.188 1.00 12.00 ATOM 9 N MET 1002 -1.294 1.910 0.867 1.00 12.00 ATOM 10 CA MET 1002 -2.504 2.739 0.960 1.00 12.00 ATOM 11 C MET 1002 -2.732 3.466 -0.366 1.00 12.00 ATOM 12 O MET 1002 -3.849 3.476 -0.904 1.00 12.00 ATOM 13 CB MET 1002 -2.405 3.707 2.136 1.00 12.00 ATOM 14 CG MET 1002 -2.247 2.973 3.442 1.00 12.00 ATOM 15 SD MET 1002 -3.717 1.906 3.651 1.00 12.00 ATOM 16 CE MET 1002 -5.009 3.154 3.640 1.00 12.00 ATOM 17 N GLU 1003 -1.679 4.081 -0.935 1.00 12.00 ATOM 18 CA GLU 1003 -1.862 4.857 -2.169 1.00 12.00 ATOM 19 C GLU 1003 -2.304 3.928 -3.301 1.00 12.00 ATOM 20 O GLU 1003 -3.259 4.225 -4.034 1.00 12.00 ATOM 21 CB GLU 1003 -0.549 5.516 -2.607 1.00 12.00 ATOM 22 CG GLU 1003 0.110 6.494 -1.648 1.00 12.00 ATOM 23 CD GLU 1003 1.392 7.118 -2.110 1.00 12.00 ATOM 24 OE1 GLU 1003 1.915 6.883 -3.189 1.00 12.00 ATOM 25 OE2 GLU 1003 1.874 7.896 -1.260 1.00 12.00 ATOM 26 N LEU 1004 -1.632 2.774 -3.465 1.00 12.00 ATOM 27 CA LEU 1004 -1.967 1.883 -4.585 1.00 12.00 ATOM 28 C LEU 1004 -3.398 1.366 -4.421 1.00 12.00 ATOM 29 O LEU 1004 -4.196 1.388 -5.370 1.00 12.00 ATOM 30 CB LEU 1004 -0.906 0.777 -4.628 1.00 12.00 ATOM 31 CG LEU 1004 0.538 1.213 -4.831 1.00 12.00 ATOM 32 CD1 LEU 1004 1.464 0.002 -4.850 1.00 12.00 ATOM 33 CD2 LEU 1004 0.632 1.972 -6.149 1.00 12.00 ATOM 34 N LEU 1005 -3.764 0.902 -3.212 1.00 12.00 ATOM 35 CA LEU 1005 -5.101 0.325 -3.023 1.00 12.00 ATOM 36 C LEU 1005 -6.164 1.400 -3.256 1.00 12.00 ATOM 37 O LEU 1005 -7.149 1.177 -3.976 1.00 12.00 ATOM 38 CB LEU 1005 -5.141 -0.298 -1.622 1.00 12.00 ATOM 39 CG LEU 1005 -4.139 -1.406 -1.331 1.00 12.00 ATOM 40 CD1 LEU 1005 -4.308 -1.917 0.096 1.00 12.00 ATOM 41 CD2 LEU 1005 -4.366 -2.537 -2.327 1.00 12.00 ATOM 42 N SER 1006 -5.987 2.596 -2.667 1.00 12.00 ATOM 43 CA SER 1006 -7.016 3.637 -2.797 1.00 12.00 ATOM 44 C SER 1006 -7.147 4.051 -4.264 1.00 12.00 ATOM 45 O SER 1006 -8.260 4.142 -4.803 1.00 12.00 ATOM 46 CB SER 1006 -6.711 4.825 -1.894 1.00 12.00 ATOM 47 OG SER 1006 -5.465 5.421 -2.206 1.00 12.00 ATOM 48 N PRO 1007 -6.018 4.298 -4.950 1.00 12.00 ATOM 49 CA PRO 1007 -6.092 4.773 -6.339 1.00 12.00 ATOM 50 C PRO 1007 -6.737 3.698 -7.216 1.00 12.00 ATOM 51 O PRO 1007 -7.643 3.985 -8.013 1.00 12.00 ATOM 52 CB PRO 1007 -4.620 4.984 -6.716 1.00 12.00 ATOM 53 CG PRO 1007 -3.876 3.988 -5.868 1.00 12.00 ATOM 54 CD PRO 1007 -4.651 3.929 -4.559 1.00 12.00 ATOM 55 N PRO 1008 -6.299 2.433 -7.084 1.00 12.00 ATOM 56 CA PRO 1008 -6.831 1.378 -7.957 1.00 12.00 ATOM 57 C PRO 1008 -8.327 1.197 -7.692 1.00 12.00 ATOM 58 O PRO 1008 -9.137 1.140 -8.629 1.00 12.00 ATOM 59 CB PRO 1008 -6.040 0.136 -7.526 1.00 12.00 ATOM 60 CG PRO 1008 -5.713 0.390 -6.079 1.00 12.00 ATOM 61 CD PRO 1008 -5.486 1.893 -5.986 1.00 12.00 ATOM 62 N LEU 1009 -8.733 1.118 -6.413 1.00 12.00 ATOM 63 CA LEU 1009 -10.149 0.867 -6.107 1.00 12.00 ATOM 64 C LEU 1009 -10.998 2.036 -6.611 1.00 12.00 ATOM 65 O LEU 1009 -12.031 1.836 -7.269 1.00 12.00 ATOM 66 CB LEU 1009 -10.259 0.621 -4.598 1.00 12.00 ATOM 67 CG LEU 1009 -9.473 -0.552 -4.030 1.00 12.00 ATOM 68 CD1 LEU 1009 -9.688 -0.660 -2.524 1.00 12.00 ATOM 69 CD2 LEU 1009 -9.940 -1.826 -4.723 1.00 12.00 ATOM 70 N ARG 1010 -10.581 3.283 -6.329 1.00 12.00 ATOM 71 CA ARG 1010 -11.401 4.437 -6.724 1.00 12.00 ATOM 72 C ARG 1010 -11.500 4.501 -8.249 1.00 12.00 ATOM 73 O ARG 1010 -12.594 4.667 -8.810 1.00 12.00 ATOM 74 CB ARG 1010 -10.806 5.747 -6.185 1.00 12.00 ATOM 75 CG ARG 1010 -10.685 5.830 -4.670 1.00 12.00 ATOM 76 CD ARG 1010 -10.100 7.129 -4.235 1.00 12.00 ATOM 77 NE ARG 1010 -9.981 7.216 -2.786 1.00 12.00 ATOM 78 CZ ARG 1010 -9.488 8.278 -2.157 1.00 12.00 ATOM 79 NH1 ARG 1010 -8.887 9.260 -2.819 1.00 12.00 ATOM 80 NH2 ARG 1010 -9.552 8.336 -0.829 1.00 12.00 ATOM 81 N ASP 1011 -10.367 4.355 -8.959 1.00 12.00 ATOM 82 CA ASP 1011 -10.397 4.485 -10.422 1.00 12.00 ATOM 83 C ASP 1011 -11.260 3.372 -11.020 1.00 12.00 ATOM 84 O ASP 1011 -12.122 3.623 -11.875 1.00 12.00 ATOM 85 CB ASP 1011 -8.996 4.561 -10.997 1.00 12.00 ATOM 86 CG ASP 1011 -8.182 5.738 -10.485 1.00 12.00 ATOM 87 OD1 ASP 1011 -8.680 6.535 -9.665 1.00 12.00 ATOM 88 OD2 ASP 1011 -7.021 5.839 -10.914 1.00 12.00 ATOM 89 N ILE 1012 -11.062 2.117 -10.577 1.00 12.00 ATOM 90 CA ILE 1012 -11.811 1.002 -11.173 1.00 12.00 ATOM 91 C ILE 1012 -13.305 1.178 -10.894 1.00 12.00 ATOM 92 O ILE 1012 -14.142 1.050 -11.800 1.00 12.00 ATOM 93 CB ILE 1012 -11.266 -0.365 -10.624 1.00 12.00 ATOM 94 CG1 ILE 1012 -9.767 -0.505 -10.986 1.00 12.00 ATOM 95 CG2 ILE 1012 -12.095 -1.578 -11.114 1.00 12.00 ATOM 96 CD1 ILE 1012 -9.111 -1.824 -10.494 1.00 12.00 ATOM 97 N ASP 1013 -13.677 1.489 -9.640 1.00 12.00 ATOM 98 CA ASP 1013 -15.104 1.594 -9.303 1.00 12.00 ATOM 99 C ASP 1013 -15.735 2.744 -10.088 1.00 12.00 ATOM 100 O ASP 1013 -16.807 2.591 -10.692 1.00 12.00 ATOM 101 CB ASP 1013 -15.310 1.678 -7.803 1.00 12.00 ATOM 102 CG ASP 1013 -14.782 0.475 -7.038 1.00 12.00 ATOM 103 OD1 ASP 1013 -14.237 -0.465 -7.649 1.00 12.00 ATOM 104 OD2 ASP 1013 -14.914 0.500 -5.803 1.00 12.00 ATOM 105 N LEU 1014 -15.083 3.920 -10.113 1.00 12.00 ATOM 106 CA LEU 1014 -15.685 5.078 -10.789 1.00 12.00 ATOM 107 C LEU 1014 -15.820 4.788 -12.285 1.00 12.00 ATOM 108 O LEU 1014 -16.880 5.018 -12.885 1.00 12.00 ATOM 109 CB LEU 1014 -14.818 6.302 -10.467 1.00 12.00 ATOM 110 CG LEU 1014 -14.672 6.677 -9.000 1.00 12.00 ATOM 111 CD1 LEU 1014 -13.785 7.909 -8.849 1.00 12.00 ATOM 112 CD2 LEU 1014 -16.059 6.952 -8.430 1.00 12.00 ATOM 113 N THR 1015 -14.758 4.263 -12.921 1.00 12.00 ATOM 114 CA THR 1015 -14.811 4.038 -14.373 1.00 12.00 ATOM 115 C THR 1015 -15.886 2.997 -14.693 1.00 12.00 ATOM 116 O THR 1015 -16.713 3.193 -15.596 1.00 12.00 ATOM 117 CB THR 1015 -13.399 3.581 -14.924 1.00 12.00 ATOM 118 OG1 THR 1015 -12.458 4.646 -14.573 1.00 12.00 ATOM 119 CG2 THR 1015 -13.398 3.287 -16.433 1.00 12.00 ATOM 120 N GLY 1016 -15.912 1.874 -13.954 1.00 12.00 ATOM 121 CA GLY 1016 -16.876 0.810 -14.272 1.00 12.00 ATOM 122 C GLY 1016 -18.300 1.328 -14.065 1.00 12.00 ATOM 123 O GLY 1016 -19.175 1.146 -14.924 1.00 12.00 ATOM 124 N PRO 1017 -18.566 1.999 -12.930 1.00 12.00 ATOM 125 CA PRO 1017 -19.936 2.450 -12.649 1.00 12.00 ATOM 126 C PRO 1017 -20.367 3.474 -13.700 1.00 12.00 ATOM 127 O PRO 1017 -21.468 3.385 -14.263 1.00 12.00 ATOM 128 CB PRO 1017 -19.814 3.098 -11.263 1.00 12.00 ATOM 129 CG PRO 1017 -18.394 3.596 -11.214 1.00 12.00 ATOM 130 CD PRO 1017 -17.588 2.564 -11.991 1.00 12.00 ATOM 131 N ASP 1018 -19.507 4.464 -14.002 1.00 12.00 ATOM 132 CA ASP 1018 -19.903 5.516 -14.948 1.00 12.00 ATOM 133 C ASP 1018 -20.139 4.903 -16.330 1.00 12.00 ATOM 134 O ASP 1018 -21.156 5.178 -16.983 1.00 12.00 ATOM 135 CB ASP 1018 -18.914 6.665 -14.939 1.00 12.00 ATOM 136 CG ASP 1018 -18.770 7.345 -13.587 1.00 12.00 ATOM 137 OD1 ASP 1018 -19.434 6.945 -12.611 1.00 12.00 ATOM 138 OD2 ASP 1018 -17.960 8.285 -13.522 1.00 12.00 ATOM 139 N GLY 1019 -19.215 4.048 -16.804 1.00 12.00 ATOM 140 CA GLY 1019 -19.357 3.492 -18.157 1.00 12.00 ATOM 141 C GLY 1019 -20.617 2.629 -18.229 1.00 12.00 ATOM 142 O GLY 1019 -21.422 2.753 -19.164 1.00 12.00 ATOM 143 N SER 1020 -20.830 1.743 -17.239 1.00 12.00 ATOM 144 CA SER 1020 -21.986 0.837 -17.301 1.00 12.00 ATOM 145 C SER 1020 -23.280 1.650 -17.247 1.00 12.00 ATOM 146 O SER 1020 -24.202 1.435 -18.049 1.00 12.00 ATOM 147 CB SER 1020 -21.922 -0.208 -16.195 1.00 12.00 ATOM 148 OG SER 1020 -21.917 0.382 -14.908 1.00 12.00 ATOM 149 N LEU 1021 -23.379 2.614 -16.314 1.00 12.00 ATOM 150 CA LEU 1021 -24.630 3.371 -16.172 1.00 12.00 ATOM 151 C LEU 1021 -24.895 4.173 -17.447 1.00 12.00 ATOM 152 O LEU 1021 -26.011 4.161 -17.987 1.00 12.00 ATOM 153 CB LEU 1021 -24.507 4.232 -14.908 1.00 12.00 ATOM 154 CG LEU 1021 -24.285 3.500 -13.593 1.00 12.00 ATOM 155 CD1 LEU 1021 -24.184 4.492 -12.439 1.00 12.00 ATOM 156 CD2 LEU 1021 -25.451 2.545 -13.368 1.00 12.00 ATOM 157 N CYS 1022 -23.875 4.878 -17.969 1.00 12.00 ATOM 158 CA CYS 1022 -24.098 5.725 -19.149 1.00 12.00 ATOM 159 C CYS 1022 -24.489 4.852 -20.343 1.00 12.00 ATOM 160 O CYS 1022 -25.458 5.148 -21.058 1.00 12.00 ATOM 161 CB CYS 1022 -22.865 6.569 -19.445 1.00 12.00 ATOM 162 SG CYS 1022 -22.383 7.683 -18.106 1.00 12.00 ATOM 163 N SER 1023 -23.758 3.748 -20.581 1.00 12.00 ATOM 164 CA SER 1023 -24.045 2.918 -21.759 1.00 12.00 ATOM 165 C SER 1023 -25.447 2.318 -21.636 1.00 12.00 ATOM 166 O SER 1023 -26.244 2.362 -22.585 1.00 12.00 ATOM 167 CB SER 1023 -22.980 1.846 -21.946 1.00 12.00 ATOM 168 OG SER 1023 -22.898 0.980 -20.829 1.00 12.00 ATOM 169 N PHE 1024 -25.789 1.756 -20.463 1.00 12.00 ATOM 170 CA PHE 1024 -27.096 1.098 -20.319 1.00 12.00 ATOM 171 C PHE 1024 -28.212 2.130 -20.484 1.00 12.00 ATOM 172 O PHE 1024 -29.184 1.905 -21.221 1.00 12.00 ATOM 173 CB PHE 1024 -27.200 0.285 -19.038 1.00 12.00 ATOM 174 CG PHE 1024 -26.207 -0.827 -18.879 1.00 12.00 ATOM 175 CD1 PHE 1024 -24.980 -0.587 -18.262 1.00 12.00 ATOM 176 CD2 PHE 1024 -26.501 -2.113 -19.326 1.00 12.00 ATOM 177 CE1 PHE 1024 -24.049 -1.597 -18.097 1.00 12.00 ATOM 178 CE2 PHE 1024 -25.585 -3.153 -19.177 1.00 12.00 ATOM 179 CZ PHE 1024 -24.343 -2.879 -18.574 1.00 12.00 ATOM 180 N GLU 1025 -28.098 3.292 -19.815 1.00 12.00 ATOM 181 CA GLU 1025 -29.180 4.284 -19.880 1.00 12.00 ATOM 182 C GLU 1025 -29.332 4.788 -21.316 1.00 12.00 ATOM 183 O GLU 1025 -30.447 4.857 -21.853 1.00 12.00 ATOM 184 CB GLU 1025 -28.867 5.501 -19.001 1.00 12.00 ATOM 185 CG GLU 1025 -28.664 5.269 -17.512 1.00 12.00 ATOM 186 CD GLU 1025 -28.359 6.481 -16.685 1.00 12.00 ATOM 187 OE1 GLU 1025 -28.269 7.612 -17.140 1.00 12.00 ATOM 188 OE2 GLU 1025 -28.193 6.203 -15.479 1.00 12.00 ATOM 189 N THR 1026 -28.216 5.139 -21.979 1.00 12.00 ATOM 190 CA THR 1026 -28.314 5.701 -23.334 1.00 12.00 ATOM 191 C THR 1026 -28.901 4.656 -24.284 1.00 12.00 ATOM 192 O THR 1026 -29.820 4.948 -25.063 1.00 12.00 ATOM 193 CB THR 1026 -26.900 6.198 -23.842 1.00 12.00 ATOM 194 OG1 THR 1026 -26.441 7.193 -22.872 1.00 12.00 ATOM 195 CG2 THR 1026 -26.927 6.759 -25.272 1.00 12.00 ATOM 196 N ALA 1027 -28.397 3.409 -24.234 1.00 12.00 ATOM 197 CA ALA 1027 -28.874 2.389 -25.179 1.00 12.00 ATOM 198 C ALA 1027 -30.358 2.113 -24.933 1.00 12.00 ATOM 199 O ALA 1027 -31.163 2.077 -25.875 1.00 12.00 ATOM 200 CB ALA 1027 -28.046 1.118 -25.028 1.00 12.00 ATOM 201 N ASP 1028 -30.761 1.927 -23.664 1.00 12.00 ATOM 202 CA ASP 1028 -32.162 1.584 -23.382 1.00 12.00 ATOM 203 C ASP 1028 -33.071 2.738 -23.809 1.00 12.00 ATOM 204 O ASP 1028 -34.090 2.529 -24.484 1.00 12.00 ATOM 205 CB ASP 1028 -32.343 1.152 -21.940 1.00 12.00 ATOM 206 CG ASP 1028 -31.523 -0.068 -21.552 1.00 12.00 ATOM 207 OD1 ASP 1028 -30.785 -0.619 -22.392 1.00 12.00 ATOM 208 OD2 ASP 1028 -31.625 -0.455 -20.377 1.00 12.00 ATOM 209 N ASP 1029 -32.719 3.983 -23.443 1.00 12.00 ATOM 210 CA ASP 1029 -33.598 5.117 -23.763 1.00 12.00 ATOM 211 C ASP 1029 -33.699 5.277 -25.281 1.00 12.00 ATOM 212 O ASP 1029 -34.799 5.424 -25.835 1.00 12.00 ATOM 213 CB ASP 1029 -33.163 6.373 -23.033 1.00 12.00 ATOM 214 CG ASP 1029 -33.176 6.243 -21.519 1.00 12.00 ATOM 215 OD1 ASP 1029 -33.522 5.171 -20.985 1.00 12.00 ATOM 216 OD2 ASP 1029 -32.815 7.240 -20.873 1.00 12.00 ATOM 217 N PHE 1030 -32.559 5.239 -25.994 1.00 12.00 ATOM 218 CA PHE 1030 -32.594 5.465 -27.446 1.00 12.00 ATOM 219 C PHE 1030 -33.397 4.351 -28.120 1.00 12.00 ATOM 220 O PHE 1030 -34.270 4.614 -28.961 1.00 12.00 ATOM 221 CB PHE 1030 -31.208 5.663 -28.038 1.00 12.00 ATOM 222 CG PHE 1030 -30.421 6.821 -27.504 1.00 12.00 ATOM 223 CD1 PHE 1030 -29.587 6.651 -26.400 1.00 12.00 ATOM 224 CD2 PHE 1030 -30.495 8.073 -28.111 1.00 12.00 ATOM 225 CE1 PHE 1030 -28.845 7.701 -25.891 1.00 12.00 ATOM 226 CE2 PHE 1030 -29.761 9.153 -27.622 1.00 12.00 ATOM 227 CZ PHE 1030 -28.947 8.961 -26.491 1.00 12.00 ATOM 228 N TYR 1031 -33.135 3.082 -27.761 1.00 12.00 ATOM 229 CA TYR 1031 -33.824 1.972 -28.435 1.00 12.00 ATOM 230 C TYR 1031 -35.325 2.051 -28.151 1.00 12.00 ATOM 231 O TYR 1031 -36.153 1.940 -29.067 1.00 12.00 ATOM 232 CB TYR 1031 -33.237 0.622 -27.999 1.00 12.00 ATOM 233 CG TYR 1031 -31.762 0.442 -28.302 1.00 12.00 ATOM 234 CD1 TYR 1031 -30.780 0.821 -27.379 1.00 12.00 ATOM 235 CD2 TYR 1031 -31.341 -0.086 -29.521 1.00 12.00 ATOM 236 CE1 TYR 1031 -29.424 0.694 -27.676 1.00 12.00 ATOM 237 CE2 TYR 1031 -29.992 -0.210 -29.832 1.00 12.00 ATOM 238 CZ TYR 1031 -29.034 0.191 -28.913 1.00 12.00 ATOM 239 OH TYR 1031 -27.720 0.099 -29.274 1.00 12.00 ATOM 240 N ASP 1032 -35.714 2.258 -26.880 1.00 12.00 ATOM 241 CA ASP 1032 -37.145 2.265 -26.543 1.00 12.00 ATOM 242 C ASP 1032 -37.835 3.431 -27.252 1.00 12.00 ATOM 243 O ASP 1032 -38.897 3.263 -27.870 1.00 12.00 ATOM 244 CB ASP 1032 -37.357 2.237 -25.042 1.00 12.00 ATOM 245 CG ASP 1032 -36.767 1.015 -24.357 1.00 12.00 ATOM 246 OD1 ASP 1032 -36.173 0.147 -25.027 1.00 12.00 ATOM 247 OD2 ASP 1032 -36.901 0.951 -23.124 1.00 12.00 ATOM 248 N ASP 1033 -37.244 4.638 -27.196 1.00 12.00 ATOM 249 CA ASP 1033 -37.905 5.806 -27.796 1.00 12.00 ATOM 250 C ASP 1033 -38.024 5.610 -29.308 1.00 12.00 ATOM 251 O ASP 1033 -39.094 5.825 -29.896 1.00 12.00 ATOM 252 CB ASP 1033 -37.220 7.096 -27.388 1.00 12.00 ATOM 253 CG ASP 1033 -37.207 7.341 -25.888 1.00 12.00 ATOM 254 OD1 ASP 1033 -37.731 6.516 -25.114 1.00 12.00 ATOM 255 OD2 ASP 1033 -36.644 8.378 -25.500 1.00 12.00 ATOM 256 N PRO 1034 -36.935 5.185 -29.974 1.00 12.00 ATOM 257 CA PRO 1034 -36.975 5.055 -31.437 1.00 12.00 ATOM 258 C PRO 1034 -37.994 3.984 -31.831 1.00 12.00 ATOM 259 O PRO 1034 -38.829 4.196 -32.722 1.00 12.00 ATOM 260 CB PRO 1034 -35.548 4.614 -31.788 1.00 12.00 ATOM 261 CG PRO 1034 -35.083 3.865 -30.568 1.00 12.00 ATOM 262 CD PRO 1034 -35.723 4.592 -29.393 1.00 12.00 ATOM 263 N CYS 1035 -37.963 2.813 -31.169 1.00 12.00 ATOM 264 CA CYS 1035 -38.869 1.725 -31.561 1.00 12.00 ATOM 265 C CYS 1035 -40.319 2.153 -31.326 1.00 12.00 ATOM 266 O CYS 1035 -41.183 1.984 -32.200 1.00 12.00 ATOM 267 CB CYS 1035 -38.528 0.445 -30.810 1.00 12.00 ATOM 268 SG CYS 1035 -36.851 -0.166 -31.097 1.00 12.00 ATOM 269 N PHE 1036 -40.620 2.732 -30.150 1.00 12.00 ATOM 270 CA PHE 1036 -42.013 3.091 -29.846 1.00 12.00 ATOM 271 C PHE 1036 -42.494 4.160 -30.828 1.00 12.00 ATOM 272 O PHE 1036 -43.589 4.052 -31.401 1.00 12.00 ATOM 273 CB PHE 1036 -42.210 3.470 -28.386 1.00 12.00 ATOM 274 CG PHE 1036 -41.873 2.412 -27.379 1.00 12.00 ATOM 275 CD1 PHE 1036 -40.582 2.325 -26.860 1.00 12.00 ATOM 276 CD2 PHE 1036 -42.845 1.518 -26.933 1.00 12.00 ATOM 277 CE1 PHE 1036 -40.247 1.363 -25.925 1.00 12.00 ATOM 278 CE2 PHE 1036 -42.539 0.536 -25.992 1.00 12.00 ATOM 279 CZ PHE 1036 -41.222 0.453 -25.504 1.00 12.00 ATOM 280 N ASP 1037 -41.687 5.211 -31.059 1.00 12.00 ATOM 281 CA ASP 1037 -42.136 6.302 -31.935 1.00 12.00 ATOM 282 C ASP 1037 -42.339 5.772 -33.355 1.00 12.00 ATOM 283 O ASP 1037 -43.369 6.036 -33.993 1.00 12.00 ATOM 284 CB ASP 1037 -41.209 7.498 -31.844 1.00 12.00 ATOM 285 CG ASP 1037 -41.101 8.092 -30.449 1.00 12.00 ATOM 286 OD1 ASP 1037 -41.745 7.594 -29.505 1.00 12.00 ATOM 287 OD2 ASP 1037 -40.342 9.066 -30.318 1.00 12.00 ATOM 288 N SER 1038 -41.371 5.000 -33.882 1.00 12.00 ATOM 289 CA SER 1038 -41.482 4.529 -35.269 1.00 12.00 ATOM 290 C SER 1038 -42.696 3.608 -35.405 1.00 12.00 ATOM 291 O SER 1038 -43.505 3.753 -36.333 1.00 12.00 ATOM 292 CB SER 1038 -40.196 3.849 -35.722 1.00 12.00 ATOM 293 OG SER 1038 -39.881 2.726 -34.919 1.00 12.00 ATOM 294 N PRO 1039 -42.863 2.648 -34.477 1.00 12.00 ATOM 295 CA PRO 1039 -43.970 1.690 -34.605 1.00 12.00 ATOM 296 C PRO 1039 -45.305 2.429 -34.503 1.00 12.00 ATOM 297 O PRO 1039 -46.213 2.219 -35.320 1.00 12.00 ATOM 298 CB PRO 1039 -43.763 0.755 -33.405 1.00 12.00 ATOM 299 CG PRO 1039 -43.090 1.621 -32.375 1.00 12.00 ATOM 300 CD PRO 1039 -42.193 2.558 -33.173 1.00 12.00 ATOM 301 N ASP 1040 -45.455 3.321 -33.508 1.00 12.00 ATOM 302 CA ASP 1040 -46.744 4.001 -33.320 1.00 12.00 ATOM 303 C ASP 1040 -47.049 4.872 -34.541 1.00 12.00 ATOM 304 O ASP 1040 -48.162 4.837 -35.085 1.00 12.00 ATOM 305 CB ASP 1040 -46.787 4.745 -32.000 1.00 12.00 ATOM 306 CG ASP 1040 -46.598 3.855 -30.783 1.00 12.00 ATOM 307 OD1 ASP 1040 -46.426 2.629 -30.924 1.00 12.00 ATOM 308 OD2 ASP 1040 -46.611 4.418 -29.676 1.00 12.00 ATOM 309 N LEU 1041 -46.067 5.662 -35.010 1.00 12.00 ATOM 310 CA LEU 1041 -46.332 6.573 -36.132 1.00 12.00 ATOM 311 C LEU 1041 -46.676 5.763 -37.383 1.00 12.00 ATOM 312 O LEU 1041 -47.659 6.055 -38.081 1.00 12.00 ATOM 313 CB LEU 1041 -45.104 7.477 -36.292 1.00 12.00 ATOM 314 CG LEU 1041 -44.725 8.345 -35.102 1.00 12.00 ATOM 315 CD1 LEU 1041 -43.489 9.180 -35.421 1.00 12.00 ATOM 316 CD2 LEU 1041 -45.904 9.253 -34.771 1.00 12.00 ATOM 317 N ARG 1042 -45.889 4.717 -37.690 1.00 12.00 ATOM 318 CA ARG 1042 -46.131 3.954 -38.923 1.00 12.00 ATOM 319 C ARG 1042 -47.500 3.275 -38.846 1.00 12.00 ATOM 320 O ARG 1042 -48.297 3.341 -39.794 1.00 12.00 ATOM 321 CB ARG 1042 -45.037 2.898 -39.143 1.00 12.00 ATOM 322 CG ARG 1042 -43.623 3.447 -39.272 1.00 12.00 ATOM 323 CD ARG 1042 -42.628 2.358 -39.483 1.00 12.00 ATOM 324 NE ARG 1042 -41.272 2.875 -39.608 1.00 12.00 ATOM 325 CZ ARG 1042 -40.210 2.100 -39.801 1.00 12.00 ATOM 326 NH1 ARG 1042 -40.289 0.777 -39.699 1.00 12.00 ATOM 327 NH2 ARG 1042 -39.030 2.661 -40.053 1.00 12.00 ATOM 328 N PHE 1043 -47.813 2.619 -37.715 1.00 12.00 ATOM 329 CA PHE 1043 -49.084 1.885 -37.621 1.00 12.00 ATOM 330 C PHE 1043 -50.253 2.867 -37.722 1.00 12.00 ATOM 331 O PHE 1043 -51.210 2.642 -38.477 1.00 12.00 ATOM 332 CB PHE 1043 -49.146 0.984 -36.398 1.00 12.00 ATOM 333 CG PHE 1043 -48.097 -0.082 -36.309 1.00 12.00 ATOM 334 CD1 PHE 1043 -46.885 0.179 -35.672 1.00 12.00 ATOM 335 CD2 PHE 1043 -48.323 -1.350 -36.842 1.00 12.00 ATOM 336 CE1 PHE 1043 -45.903 -0.790 -35.570 1.00 12.00 ATOM 337 CE2 PHE 1043 -47.354 -2.348 -36.758 1.00 12.00 ATOM 338 CZ PHE 1043 -46.129 -2.051 -36.133 1.00 12.00 ATOM 339 N PHE 1044 -50.200 3.985 -36.977 1.00 12.00 ATOM 340 CA PHE 1044 -51.332 4.922 -36.980 1.00 12.00 ATOM 341 C PHE 1044 -51.508 5.513 -38.380 1.00 12.00 ATOM 342 O PHE 1044 -52.625 5.559 -38.916 1.00 12.00 ATOM 343 CB PHE 1044 -51.223 5.971 -35.884 1.00 12.00 ATOM 344 CG PHE 1044 -51.175 5.454 -34.478 1.00 12.00 ATOM 345 CD1 PHE 1044 -49.950 5.153 -33.884 1.00 12.00 ATOM 346 CD2 PHE 1044 -52.346 5.286 -33.740 1.00 12.00 ATOM 347 CE1 PHE 1044 -49.878 4.680 -32.586 1.00 12.00 ATOM 348 CE2 PHE 1044 -52.307 4.812 -32.430 1.00 12.00 ATOM 349 CZ PHE 1044 -51.061 4.490 -31.863 1.00 12.00 ATOM 350 N GLU 1045 -50.411 5.965 -39.013 1.00 12.00 ATOM 351 CA GLU 1045 -50.537 6.611 -40.327 1.00 12.00 ATOM 352 C GLU 1045 -51.068 5.602 -41.347 1.00 12.00 ATOM 353 O GLU 1045 -52.000 5.898 -42.110 1.00 12.00 ATOM 354 CB GLU 1045 -49.175 7.099 -40.835 1.00 12.00 ATOM 355 CG GLU 1045 -48.425 8.118 -39.992 1.00 12.00 ATOM 356 CD GLU 1045 -47.098 8.572 -40.519 1.00 12.00 ATOM 357 OE1 GLU 1045 -46.607 8.172 -41.565 1.00 12.00 ATOM 358 OE2 GLU 1045 -46.544 9.395 -39.762 1.00 12.00 ATOM 359 N ASP 1046 -50.500 4.383 -41.379 1.00 12.00 ATOM 360 CA ASP 1046 -50.921 3.405 -42.392 1.00 12.00 ATOM 361 C ASP 1046 -52.390 3.037 -42.172 1.00 12.00 ATOM 362 O ASP 1046 -53.191 3.022 -43.118 1.00 12.00 ATOM 363 CB ASP 1046 -49.982 2.216 -42.432 1.00 12.00 ATOM 364 CG ASP 1046 -48.543 2.576 -42.765 1.00 12.00 ATOM 365 OD1 ASP 1046 -48.228 3.763 -42.975 1.00 12.00 ATOM 366 OD2 ASP 1046 -47.729 1.638 -42.796 1.00 12.00 ATOM 367 N LEU 1047 -52.784 2.745 -40.920 1.00 12.00 ATOM 368 CA LEU 1047 -54.165 2.311 -40.668 1.00 12.00 ATOM 369 C LEU 1047 -55.132 3.442 -41.022 1.00 12.00 ATOM 370 O LEU 1047 -56.139 3.227 -41.713 1.00 12.00 ATOM 371 CB LEU 1047 -54.246 1.856 -39.206 1.00 12.00 ATOM 372 CG LEU 1047 -53.342 0.705 -38.790 1.00 12.00 ATOM 373 CD1 LEU 1047 -53.542 0.374 -37.315 1.00 12.00 ATOM 374 CD2 LEU 1047 -53.675 -0.507 -39.652 1.00 12.00 ATOM 375 N ASP 1048 -54.847 4.677 -40.571 1.00 12.00 ATOM 376 CA ASP 1048 -55.783 5.783 -40.819 1.00 12.00 ATOM 377 C ASP 1048 -55.890 6.039 -42.323 1.00 12.00 ATOM 378 O ASP 1048 -56.996 6.165 -42.870 1.00 12.00 ATOM 379 CB ASP 1048 -55.416 7.007 -40.005 1.00 12.00 ATOM 380 CG ASP 1048 -55.423 6.776 -38.502 1.00 12.00 ATOM 381 OD1 ASP 1048 -55.714 5.654 -38.043 1.00 12.00 ATOM 382 OD2 ASP 1048 -55.115 7.745 -37.789 1.00 12.00 ATOM 383 N PRO 1049 -54.749 6.108 -43.032 1.00 12.00 ATOM 384 CA PRO 1049 -54.795 6.428 -44.465 1.00 12.00 ATOM 385 C PRO 1049 -55.538 5.322 -45.216 1.00 12.00 ATOM 386 O PRO 1049 -56.422 5.595 -46.041 1.00 12.00 ATOM 387 CB PRO 1049 -53.313 6.466 -44.862 1.00 12.00 ATOM 388 CG PRO 1049 -52.651 5.510 -43.907 1.00 12.00 ATOM 389 CD PRO 1049 -53.416 5.668 -42.600 1.00 12.00 ATOM 390 N ARG 1050 -55.210 4.047 -44.942 1.00 12.00 ATOM 391 CA ARG 1050 -55.839 2.950 -45.691 1.00 12.00 ATOM 392 C ARG 1050 -57.343 2.931 -45.409 1.00 12.00 ATOM 393 O ARG 1050 -58.163 2.840 -46.335 1.00 12.00 ATOM 394 CB ARG 1050 -55.221 1.596 -45.312 1.00 12.00 ATOM 395 CG ARG 1050 -53.727 1.468 -45.577 1.00 12.00 ATOM 396 CD ARG 1050 -53.212 0.127 -45.181 1.00 12.00 ATOM 397 NE ARG 1050 -51.782 -0.003 -45.431 1.00 12.00 ATOM 398 CZ ARG 1050 -51.092 -1.106 -45.161 1.00 12.00 ATOM 399 NH1 ARG 1050 -51.622 -2.103 -44.461 1.00 12.00 ATOM 400 NH2 ARG 1050 -49.825 -1.195 -45.557 1.00 12.00 ATOM 401 N LEU 1051 -57.744 3.032 -44.130 1.00 12.00 ATOM 402 CA LEU 1051 -59.173 2.942 -43.799 1.00 12.00 ATOM 403 C LEU 1051 -59.922 4.116 -44.432 1.00 12.00 ATOM 404 O LEU 1051 -60.973 3.934 -45.064 1.00 12.00 ATOM 405 CB LEU 1051 -59.290 2.878 -42.272 1.00 12.00 ATOM 406 CG LEU 1051 -58.605 1.712 -41.575 1.00 12.00 ATOM 407 CD1 LEU 1051 -58.814 1.792 -40.067 1.00 12.00 ATOM 408 CD2 LEU 1051 -59.186 0.413 -42.120 1.00 12.00 TER
Greetings
Gert Vriend
Tel. 49-6221-387473