1) Search for all entries in SwissProt which have the name Alzheimer in their description field.
How many hits do you receive from this query?
21 (aug 2017) with the term in the DE field, and 315 (aug 2017) that have
the word just anywhere.The first search is better because it doesn't, for example, give you
ACES_TORCA that is found because one article title reads: "Structure of acetylcholinesterase
complexed with E2020 (Aricept(R)): implications for the design of new anti-Alzheimer drugs".
2) Search for all entries in SwissProt which have glycoprotein in their description field. How many hits
do you get from your query?
2390 (aug 2017)
3/4) The purpose of questions 3 and 4 is to find out which of the 20 proteins have a sugar bound.
Approaches:
The query de:glycoprotein de:Alzheimer gives 2 hits: a4_mouse and a4_rat.
Remember that it is very likely that a word like glycoprotein was not put in the DE field by the
submitter of the sequence. It is a feature of the amino acid sequence and therefore it is annotated
in the FT records. You can find the list of many FT records at
http://web.expasy.org/docs/userman.html#FT_line
The record for glycosilation is FT:CARBOHYD.
The query de:alzheimer ft:carbohyd gives ~10 hits, among which a4_mouse and a4_rat.