Suggest proline mutations


This server will suggest stabilizing proline mutations.


The basis of the algoritm for the prediction of the conformation of the new side chain is described in:
The use of position specific rotamers in model building by homology.
G. Chinea, G. Padron, R.W.W.Hooft, C.Sander, G.Vriend
PROTEINS (1995) 23, 415-421.
This server will work on maximally 500 residues, starting with the first residue (the one you are prompted for). You typically enter residue number 1 here, and if your PDB files holds fewer than 501 residues, each position will be analysed for the possibility to place a proline there to stabilize the protein.
The interactive version of WHAT IF does not have this limitation.
Either Choose a pdb-file,
Or Choose your own file
Number of first residue

If you have detected any error, or have any question or suggestion, please send an Email to Gert Vriend.
Roland Krause, Maarten L Hekkelman, Jens E Nielsen, Gert Vriend.

Last modified Mon Jan 29 12:33:00 2018