This server will suggest stabilizing proline mutations.
Methods
The basis of the algoritm for the prediction of the conformation
of the new side chain is described in: The use of position specific rotamers in model building by homology.
G. Chinea, G. Padron, R.W.W.Hooft, C.Sander, G.Vriend
PROTEINS (1995) 23, 415-421.
This server will work on maximally 500 residues, starting with the first
residue (the one you are prompted for). You typically enter residue number 1 here,
and if your PDB files holds fewer than 501 residues, each position will be analysed
for the possibility to place a proline there to stabilize the protein.
The interactive version of
WHAT IF does not have
this limitation.
If you have detected any error, or have any question or suggestion,
please send an Email to Gert Vriend.
Roland Krause, Maarten L Hekkelman, Jens E Nielsen,
Gert Vriend.
