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This article/website combination discusses that the frequency pattern of amino acids observed in colums in MSAs are in two dimensions best described by Entropy and Variability; and nothing more. But much more can be said about the application of Entropy-Variability analyses. |
When we analysed many thousands of models made by AlphaFold, we observed a series of nice and useful models, but a much larger series totally useless models. We made a alphafold models website that discusses this problem. These pages by necessity mention the Entropy and Variability story.
The analysis of problems caused genetic mutations in the coding part of the human genome is a large and important research field, and the HOPE project helps with one aspect of this research. It seems likely that EV-plots will one day get incorporated in HOPE.
When we made the GPCRDB in the 90's we already focused on mutations, and actually, the whole Entropy-Variability research was initiated by the idea that that variability patterns should be informative when designing mutations. Nowadays your best resource for the computational aspects of mutation design is a 3DM database. Bio-prodict makes such databases and it seems likely that they will incorporate EV-related data to their systems, one day or another.
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